Formation of mammalian erythrocytes: chromatin condensation and enucleation
نویسندگان
چکیده
منابع مشابه
Formation of mammalian erythrocytes: chromatin condensation and enucleation Citation
In all vertebrates the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation – the process by which the nucleus is extruded by budding off from the erythroblast – is unique to mammals. Enucleation has critical physiological and evolutionary significance in that it allows an elevation of hemoglobin levels in the blood and...
متن کاملFormation of mammalian erythrocytes: chromatin condensation and enucleation.
In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to mammals. Enucleation has critical physiological and evolutionary significance in that it allows an elevation of hemoglobin levels in the blood and ...
متن کاملHDAC2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts
Background. Mammalian erythroid cells undergo chromatin condensation and enucleation in their final stages of differentiation. We previously reported that Rac GTPases and their downstream target mDia2 are required for enucleation of in vitro cultured mouse fetal liver erythroblasts. However, it is not clear how chromatin condensation is achieved and whether it is required for enucleation. Desig...
متن کاملHistone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts.
BACKGROUND During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver erythroblasts. However, it is not clear how chromatin condensation is achieved ...
متن کاملsimulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2011
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2011.04.003